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discard it and obtain a replacement

While most people find this unnecessary once they develop good technique, it can be helpful for people who are especially needle-sensitive or just starting out

Very-low-energy diets and total diet replacement programmes should only be undertaken under clinical supervision in line with NICE guidance

Participants dropping 15-20% of body weight with structured support showed only 10-15% lean mass loss versus the expected 25-35% without intervention

Together, these pathways represent complementary approaches to metabolic regulation, making dual agonists like tirzepatide valuable tools for studying integrated metabolic control

Our team of doctors and prescribers, and our support staff, are all UK-based