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New or worsening heartburn that does not respond to over-the-counter antacids, as this may indicate gastroesophageal reflux disease requiring treatment

However, at higher doses or in the presence of oxidative stress and transition metals, curcumin can also interfere with COX-1 activity
However, this difference was modest and did not translate to higher discontinuation rates
"First, weight loss itself improves a lot of the things that lead to fractures in the first place

That experience is more common than most clinics prepare their patients for, and understanding why it happens can be the difference between pushing through intel

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