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In contrast, germline deletion of INHBA in mice is neonatally lethal, demonstrating the necessity of activin signaling during development 53

Approximately half of all patients who begin taking these drugs discontinue their use within the first year, however, and three-quarters have stopped after two years

Those companies, insurers say, have charged exorbitant amounts for the weight loss medicines, and the costs to insurers were unsustainable

Kate Lothman, of RTI Health Solutions, Research Triangle Park, NC, provided medical writing services during the development of the manuscript
