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The tradeoff is doubling the number of injection events per week
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As a comparison, the ECL1 of GIPR partially unwound with the presence of three proline residues (P195 ECL1 , P197 ECL1 and P199 ECL1 ), resulting in reduced interactions between ECL1 and tirzepatide compared to that in GLP-1R (Fig
Diabetes Care 2024;47(Suppl
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