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.2821882 [DOI] [PMC free article] [PubMed] [Google Scholar] 25.Mackey TK, Jarmusch AK, Xu Q, Sun K, Lu A, Aguirre S, Lim J, Bhakta S, Dorrestein PC

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Osteophytes, bone spurs growing on arthritic joints, are directly related to OA pain symptoms [61]

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For a plain explanation of why supplement style products are held to a different standard than approved drugs, see the United States Food and Drug Administration consumer guidance on dietary supplements, which explains why supplement style products are not tested for effectiveness before they are allowed to reach the market