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We assessed the prespecified secondary outcome metabolic syndrome severity z-score (MetS-Z), abdominal obesity (estimated as android fat via dual-energy X-ray absorptiometry), and inflammation marker high-sensitivity C-reactive protein (hsCRP)

Until recently, clinicians have had limited pharmaceutical options in management this disorder

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After 1 year, liraglutide/placebo recipients switched to liraglutide 2.4mg, then 3.0mg (based on 20-week and 1-year results, respectively)

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In some cases, discontinuing GLP-1 RA therapy may be appropriate