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Although blood pressure lowering is an established mechanism for reducing MACE, the magnitude seen with GLP-1RAs is likely insufficient to explain the full extent of CV benefit (66)

What We Can Say Safely Energy use is still being studied

Another two trials from the SURMOUNT programme have recently been published [48, 49]

Multiple large clinical trials report significant reductions in cardiovascular events in adults with type 2 diabetes [5,22]
Diabetes 67 , 15381548 (2018)
