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Orlistat is currently the only FDA-approved lipase inhibitor for weight loss

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JAMA, 300 (21), 2514-2526
Indeed, the generalizability of findings to other regions and ethnic groups remains uncertain
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In silico molecular docking followed by binding free energy calculation revealed that chlorogenic acid (CGA) has a strong binding affinity for GPR-40/43 in comparison to other bioactive polyphenols

Most resolve within weeks to months as the body adjusts
