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Expired semaglutide medicines lose their efficacy and must be replaced with a new batch

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As of September 2023, of the 23,845 reports of adverse reactions with semaglutide in the US, there have been 144 cases of suicidal ideation and 2 deaths by suicide

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doi: 10.1007/s11695-024-07578-7

15 In the SURPASS-1 study, tirzepatide monotherapy at increasing doses of 5, 10, and 15 mg resulted in significant weight loss of 7, 7.8, and 9.5 kg, respectively, at week 40 in patients with T2DM, compared with a 0.7 kg decrease with placebo