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Sinus node tissue homogenization, peptide preparation, tandem mass tag (TMT) labelling, phosphopeptide enrichment, off-line peptide fractionation, and mass spectrometry measurements followed published procedures 46 and are detailed in the Supplementary material

Cox proportional hazards regression models were used to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for study outcomes

Intraoperative pulmonary aspiration Intraoperative pulmonary aspiration occurs when patients under anesthesia choke, typically on regurgitated food

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