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And yet, undeterred, dual agonism of GLP-1R and GIPR has also progressed and, in fact, achieved regulatory approval first for both T2D and obesity indications in the form of unimolecular co-agonist tirzepatide

doi:10.1517/14656566.3.6.727 171

The hormone increases insulin secretion and improves insulin sensitivity
Managing side effects often involves a degree of personalized troubleshooting

In the US, individuals with overweight or obesity using GLP-1 RAs has increased from 21,000 in 2019 to 174,000 in 2023, which is a 700% increase in usage 11

Their ability to address early-stage and progressive disease stages reinforces their importance in diabetes care
