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And part of that could be because their GLP-1 levels dont go up as high for a given meal. In those people, Yeo says, synthetic GLP-1 drugs may work better than they would in people with naturally higher levels

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Appetite Regulation Semaglutide binds GLP-1 receptors in brain regions that regulate food intake, particularly the hypothalamus and brainstem, and has powerful appetite-suppressing effects

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