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Furthermore, exenatide has been demonstrated to mitigate mitochondrial oxidative stress, reduce Ca 2 overload, inhibit fission, and close the mitochondrial permeability transition pore (mPTP), collectively preventing cardiomyocyte apoptosis by inhibiting the release of proapoptotic proteins such as cytochrome c and caspase-3 [94]

GLP-1 also helps regulate blood sugar levels by stimulating the release of insulin after meals, which can reduce the risk of insulin resistance and metabolic issues

Adderall contains a mixture of amphetamine salts that stimulate the release of norepinephrine and dopamine in the central nervous system

Currently recommended pharmacotherapies in the practice guidelines from US, Europe, and Japan Evidence-based practice guidelines for the management of NASH/NAFLD were published by the American Association for the Study of Liver Disease (AASLD) in 2012 [5], the Japan Society of Gastroenterology (JSG)Japan Society of Hepatology (JSH) in 2014 [6], and the European Association for the Study of the Liver (EASD)European Association for the Study of Diabetes (EASL)European Association for the Study of Obesity (EASO) in 2016 [7]

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With medications like Wegovy and Saxenda that are specifically approved for weight loss, and others like Ozempic and Trulicity that have shown positive results in managing blood sugar levels and concurrent weight reduction, a robust implementation of GLP-1 drugs could pave the way for a notable reduction in obesity and diabetes-related complications