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Description
In patients with pre-existing HF, an exception is noted for saxagliptin
In addition, T2DM is associated with an increased risk of stroke and mortality after stroke (79)
The STEP-HFpEF trial randomised 529 patients with obesity (BMI 30 kg/m 2 ), HFpEF (left ventricular ejection fraction [LVEF] 45%) and New York Heart Association (NYHA) Class II symptoms to once-weekly subcutaneous semaglutide 2.4 mg or placebo
Lactate acts on the lactate receptor, G-protein-coupled receptor 81 (GPR81) and augments the proliferative potential of intestinal stem cells [119,144]
You can easily update it to include Semaglutide, Tirzepatide or Liraglutide
6 How Does GLP-1 Work
