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Boxed warning thyroid C-cell tumors: GLP-1-based medications (including semaglutide, tirzepatide, and orforglipron) carry an FDA boxed warning for thyroid C-cell tumors observed in rodent studies

FOOD & DRUG ADMINISTRATION (Dec

doi: 10.2337/db06-0565

The outcomes of interest were weight CFB (%) at 52 weeks and proportion of participants losing 5% baseline fasting body weight after 12 weeks at full therapeutic dose

A comparative chart was published in 2023 by the American Diabetes Association to help with drug shortages

Nevertheless, Mounjaro is exclusively for type 2 diabetes management, while Zepbound is designed for chronic weight management for those with conditions like obesity or type 2 diabetes