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The results were, to put it mildly, staggering

Baggio LL, Yusta B, Mulvihill EE, et al

Mild fatigue and headache are common in the first two weeks and typically resolve by week three

Structural alterations of the ligand peptides as in GIP/GLP-1 dual-receptor agonists may alter these cellular processes strongly and may explain that an antagonist may activate while an agonist may block receptor signaling (4649)

Cagrilintide may offer a slightly better tolerability profile with more predictable side effect patterns, though this is based on comparative analysis rather than head-to-head trials

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