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Tirzepatide is a 39-amino acid dual agonist targeting GLP-1R and GIPR

Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

Activation of glucagon-like peptide-1 receptors in the nucleus accumbens attenuates cocaine seeking in rats

GLP-1R Agonists in Neurodegenerative Diseases A

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These observations suggest that GLP-1RAs may exert direct immunomodulatory actions beyond their metabolic effects