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Description
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and the Lys 26 side chain is prepared by fragmental synthesis, and a fully-protected fragment of Fmoc-PEG-PEG--Glu-octadecanedioic acid used in the fragmental synthesis of the Lys 26 side chain is prepared by successively coupling a chloride resin to Fmoc-PEG-OH, Fmoc-PEG-OH, Fmoc-Glu(OH)-OtBu and octadecanedioic acid mono-tert-butyl ester, cleaving, and recrystallizing to obtain PEG-PEG--Glu-Octadecanedioic Acid mono-tert-butyl ester
