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In microglia, GLP-1R activation via PI3K/Akt signaling also reduces neuroinflammation by modulating NF-B activity, decreases the production of pro-inflammatory cytokines, increases anti-inflammatory markers such as IL-10, IL-4, Arginase, and CD206, and the transformation of microglia into an anti-inflammatory state

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Although tirzepatide is not universally available, interested patients should consult with their healthcare provider regarding options for a refill as well as the availability in their region

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Depending on certain side effects, you may need less

applying treatment intensification HbA1c thresholds of 7.5% (58 mmol/mol) and 8.5% (69 mmol/mol) in separate analyses