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Erythromycin can be taken orally for patients intolerant of tetracyclines Retinoids should be avoided in patients with significant ocular problems as they can worsen symptoms and lead to a severe keratitis Troublesome ocular symptoms that persist despite of treatment should be referred to an ophthalmologist

Leptin treatment enhanced hepatic insulin sensitivity of the MKR mice by suppression of hepatic glucose production during the hyperinsulinemiceuglycemic clamp

doi: 10.1124/mol.104.008375

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In this regard, GLP-1R agonists (i.e., exenatide) improve insulin resistance suppressing pro-inflammatory phenotypes of monocytes/macrophages, and directly modulating NF-B activation and IL-1, IL-6, and TNF- expression (Yu et al., 2019)