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Phase 2 and interim phase 3 clinical trial data demonstrate robust effectiveness of GLP-1 RAs in achieving MASH resolution, with semaglutide showing additional promise for fibrosis improvement in the ongoing ESSENCE trial

[1] [2] Common examples include semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda)

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The gastrointestinal tract and the brain are involved in a complex bidirectional communication, which is mediated by the endocrine, immune and neural pathways, involving a plethora of different neurotransmitters, cytokines and peptide hormones [98]