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Similarly, in the tirzepatide treatment group, sEVtirzepatide effectively reduced blood glucose levels to an extent comparable to free tirzepatide (Figure 3D)

However, weight loss is not guaranteed and individual outcomes can vary significantly

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Glucagon typically raises blood glucose and promotes fat breakdown, but when combined with GLP-1 activation, the net effect appears to amplify energy expenditure without the problematic blood glucose elevation glucagon would cause alone

However, in a metaanalysis by Zeng et al

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