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Regul Pept 2009;156:912 [DOI] [PubMed] [Google Scholar] 41.Edholm T, Cejvan K, Abdel-Halim SM, Efendic S, Schmidt PT, Hellstrm PM

Diabetologists say that most GLP-1 patients regain lost weight within a year after they stop taking the drug, which encourages dependence

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This single substitution addresses the proteolytic half of the half-life problem