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Common strategies for extending the duration of GLP-1 RAs include: Amino Acid Sequence Optimization : Reducing rapid degradation by DPP-4 enzymes to extend the drug's half-life

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2jm) and enhanced glucose uptake into key glucoregulatory tissues (Fig

For these reasons, primary and secondary prevention of CVD in people with T2D should be a priority when considering any T2D treatment [4]

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The Bottom Line Muscle loss on GLP-1 medications is common, but it's entirely preventable with the right approach