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Combining semaglutide and testosterone replacement therapy may benefit weight management and sexual function in men, but research is limited.

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While most of the side effects from semaglutide are GI related, there are concerns that some males may also experience side effects like ED.

Altimmune will start a Phase III MASH study for pemvidutide this year, but Lillys triple agonist retatrutide and dual GLP-1/GCG agonists at Merck and Boehringer Ingelheim loom as competition.