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Hyperglycemia-induced endoplasmic reticulum stress in endothelial cells

Semaglutide and tirzepatide also reduce liver fat, with tirzepatide generally showing greater reductions than semaglutide, but neither approaches the 80%+ reductions seen with retatrutide

DPP4 can cleave various peptides, leading to inactivation and/or generation of new bioactive peptides

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Metformin increases hepatic AMP levels and AMP is a potent allosteric inhibitor of fructose 1,6-bisphosphatase, a key enzyme in gluconeogenesis (49)