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Tirzepatide came off the FDAs official drug shortage list in December 2024, and semaglutide followed in February 2025, eliminating the legal pathway that allowed compounding pharmacies to produce copies of the drugs

An exploratory signal suggested a potential lower risk of heart failure hospitalization with semaglutide compared to dapagliflozin

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However, in severe cases of dehydration, expert-guided oral intravenous rehydration solutions may be needed 5