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Current management strategies include optimising blood glucose control, dietary modifications and supportive nutrition

By analyzing data from over 27,000 23andMe participants who had taken GLP-1 medications, we uncovered direct genetic evidence that variations in drug target genes strongly influence treatment response

There is, however, controversy regarding expression of GLP1 receptors (GLP1R) in human normal and diseased thyroid and pancreas

Secondary endpoints included proportion of patients achieving 5%, 10%, 15%, and 20% weight loss, and improvements in metabolic, cardiovascular, and comorbidities after 12 months of follow-up