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In Studies 2, 3 and 5, all patients received instruction for a reduced calorie diet (approximately 500 kcal/day deficit) and increased physical activity counseling (recommended to a minimum of 150 min/week) that began with the first dose of study medication or placebo and continued throughout the trial

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[15] Therefore, achieving and maintaining a healthy weight through appropriate interventions, potentially including GLP-1 medicines when indicated, may offer overall health benefits that need to be weighed against any theoretical risks

What Are the Other Health Benefits of Tesofensine
