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Furthermore, one previous study conducted exclusively in females demonstrated that the amygdala, but not hippocampus, may be especially vulnerable to diet-induced changes in females, resulting in inflammatory dysregulation (87)

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These effects tend to be dose-dependent, class-dependent, and are more frequent during the initial stages of treatment [114, 118]
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The acylation does not appear to influence the potency of action at the GIPR, enabling tirzepatide to act as a full agonist at the human GIPR

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