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A previous Phase 2 trial in 255 patients with Parkinsons disease suggested pegsebrenatide may slow the progression of motor dysfunction, with the most pronounced effects in patients younger than 60

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Ovaries: GLP-1 reduces androgens, increases SHBG, improves PCOS morphology, and reduces ovarian inflammation

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Once blood levels reach steady state through daily dosing, the long half-life of semaglutide (approximately 7 days) means levels do not drop dramatically between doses