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While its considered rare, it primarily affects younger adults and is almost always associated with tobacco exposure

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However, while a recent report indicated that e-cigarette vaping also caused nicotine-dependent ACE2 up-regulation [42], others have revealed that neither acute inhalation of e-cigarette vapour nor e-cigarette users had increased lung ACE2 expression regardless nicotine presence in the e-liquid [43, 110]

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Thus, abuse liability is a moot point in this context

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