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The characteristic radiation of this patient's pain to the right shoulder occurs due to irritation of the phrenic nerve , which shares somatic innervation pathways with the diaphragm and gallbladder peritoneum

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Nitric oxide synthase expression in cervical spinal cord in sporadic amyotrophic lateral sclerosis

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Mol Endocrinol (2014) 28:144859

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Within the DFG-motif, the methylpiperazine moiety forms salt bridges with aspartic acid (TRKA: ASP668, TRKB: ASP710, and TRKC: ASP697)

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doi: 10.1016/j.trsl.2007.03.012

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