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The cellular protection of -cells and hepatocytes is well-supported by in vitro and animal data, anti-steatohepatitis effects are supported, while reversal of established fibrosis remains uncertain pending more definitive phase 3 outcomes (Loomba et al., 2023

Further, GLP-1RAs play a neuroprotective effect by stimulating the differentiation of nerve cells and inhibiting neuroinflammation (8), while they were also reported to inhibit liver inflammation (9)

In a randomized trial involving 25 patients with type II diabetes and psoriasis, a reduction in DLQI (22 5.85 points to 3.82 3.60 points) and PASI (15.7 11 points to 2.2 3 points) was observed after 12 weeks of treatment with liraglutide

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