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This is the mechanism that prescription GLP-1 medications amplify pharmacologically

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Before: 188 After: 121 Ive struggled with my weight my entire life

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When liraglutide binds to GLP-1R on GABAergic neurons in the NTS, it directly potentiates GABA release and suppresses food intake (Fortin et al., 2020)

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This can lead to mistakes like: Leaving medication in a hot car Carrying medication in direct sunlight Traveling without cooling protection Packing medication in checked luggage Even medications with room-temperature allowances can still be damaged by extreme heat

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Robert S, Sherwin H, Shamoon R, Hendler, et al

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