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Main menu Common skin conditions NEWS Join DermNet PRO Read more Quick links Last Reviewed: June, 2025 Author: Dr Aliana Corlett, Medical Registrar, Wellington Hospital, New Zealand (2025) Reviewing dermatologist: Dr Ian Coulson Edited by the DermNet content department Introduction Mechanism of action General uses Uses in dermatology Contraindications Benefits Side effects and risks Supply issues Glucagon-like peptide 1 (GLP-1) is an incretin hormone that plays a central role in glucose homeostasis

[DOI] [PubMed] [Google Scholar] [120].Buse JB, Drucker DJ, Taylor KL, Kim T, Walsh B, Hu H, Wilhelm K, Trautmann M, Shen LZ, Porter LE, D.-S

Front Biosci (2012) 4:1582605

Incretin-based therapies are commonly used for T2DM because the stimulation of insulin secretion and inhibition of glucagon secretion by these agents occur in a glucose-dependent manner, excluding an intrinsic risk for hypoglycemia (8)

Prunes and prune juice contain sorbitol, a natural laxative, and may be particularly beneficial