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Medicare is now paying for these drugs in certain cases, which is new as Medicare has previously been forbidden by law to cover weight loss drugs

The logic behind alternating goes like this: if semaglutide only targets GLP-1 receptors and the body has adapted to that stimulation, switching to tirzepatide introduces GIP receptor activation as a new variable

Despite these insights, the incidence of clinically significant muscle wasting attributable to GLP-1RA therapy remains undefined

Its once-weekly dosing, broad physician preference, and extensive real-world evidence drive sustained adoption

Friedman, J

[Published correction appears in Diabetes Care