list of glp 1 agonist drugs top drug companies GLP-1 Analogues Transform Metabolic Disease Management List of approved and pending

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doi:10.1007/s12017-012-8184-z 136

& Roy, D

On an individual level too, the imbalance of supply and demand of these drugs has caused concerns

For instance, exenatide, the first GLP-1-analogue developed, demonstrated to promote human monocyte differentiation into alternatively activated M2 macrophages, leading to an increase in anti-inflammatory cytokines such as IL-10 while significantly reducing pro-inflammatory cytokines, including IL-6, TNF- and IL-1 ( Furthermore, GLP-1 has been hypothesised to act as a mediator between innate and adaptive immune responses

(21) They found that semaglutide was associated with increased CTX-1 levels (p = .021) and reduced BMD at weight-bearing sites, including the lumbar spine (p = .007), total hip (p = .001), and tibia (p = .003)