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This outcome included the effect of weight loss medication use, reaching clinically significant weight loss thresholds defined as loss of 5%, 10%, and 15% of baseline weight

Taken together, these results position retatrutide as a breakthrough in comprehensive metabolic care, moving far beyond the limitations of current weight-loss and diabetes medications

They found a lower risk of HF exacerbations, all-cause emergency department visits/hospitalizations, new-onset atrial arrhythmias, new-onset acute kidney injury, and pulmonary hypertension in GLP-1RAs plus SGLT2i cohort compared with the SGLT2i-only cohort, demonstrating a possible additive effect of a combination therapy [68]

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In clinical trials, diarrhea is a common side effect, occurring in approximately 30% of patients taking Wegovy (semaglutide 2.4 mg) and 19-23% of patients taking Zepbound (tirzepatide), according to FDA prescribing information

SYMLIN can cause serious side effects, including: severe low blood sugar (hypoglycemia)
