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[DOI] [PubMed] [Google Scholar] 31.Dong M., Wen S., Zhou L

The forceful agitation can shear the delicate amino acid chains, a process called denaturation, which destroys the peptides biological activity and renders it useless for research

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Caffeine can increase the effects of several antidepressants, including amitriptyline, fluvoxamine, clomipramine, mianserin, and imipramine

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Furne JK, Levitt MD