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Systemic causes include: Stress Behets disease (inflammation of the blood vessels and tissues) Celiac disease (inflammation of the small intestine) Lupus Other illnesses affecting the blood vessels Nutritional deficiencies, such as riboflavin deficiency Chemotherapy for cancer Allergic reactions Any condition which is associated with xerostomia (dry mouth) Sexually transmitted diseases such as syphilis, gonorrhea Other infections such as acute necrotizing ulcerative gingivitis