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Its a reminder that even before new drug combinations hit the market, we dont have to wait to act

The gut microbiotaimmune-brain axis is a complex bidirectional network connecting microbial communities, the vagus nerve, the neuroendocrine system, and immune pathways (Figure 2)

[36, 37] Unlike conventional hypodermic needles, microneedle systems create transient microchannels that bypass the stratum corneum, enabling efficient transdermal transport of a wide range of molecules, including peptides, proteins, and small drugs, without reaching nerve-rich deeper layers and thus minimizing pain and risk of infection [38, 39]

Among those states that don't cover the drugs, half reported that they are considering adding coverage in the near future, the researchers added

Though the quantitative estimates depend on the national semaglutide supply, this analysis predicts that q2wk dosing could save roughly 50% more lives than q1wk dosing

Davies M, Heller S, Sreenan S, et al