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For patients aged 12 to 17 years, the setmelanotide AUC and Cmax were both 26% higher as compared to patients aged greater than or equal to 18 years [ see Dosage and Administration (2.2, 2.3)]

Even many injectable medications have relatively short half-lives requiring frequent dosing

Yes, some serious risks include pancreatitis , thyroid tumors , and kidney injury

Thyroid Function Hypothyroidism (underactive thyroid) slows metabolism and makes weight loss substantially harder regardless of medication

Novo Nordisk built an entire phase 3 program, branded CagriSema, around the idea of bolting an amylin analog onto a GLP-1 agonist