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With shortages of its blockbuster obesity now declared resolved in the USA, Denmarks Novo Nordisk (NOV: N) is moving to make the drug more widely available

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However, its future trajectory is far from linear as many uncertainties remain, e.g., acceptance of obesity as a chronic disease, budget impact faced by payers and health systems willingness and ability to pay, the readout of further cardiovascular outcomes trials after the high profile results of 2023s SELECT trial for Wegovy, or new entrants challenging first generation therapies with alternative mechanisms of action (MoA) to address shortcomings such as gastrointestinal tolerability, current drugs being injectables, or the durability and quality of weight loss which distinguishes between fat and lean body mass

The starting dose of Wegovy is 0.25 mg once weekly for the first four weeks, which helps your body adjust and minimises gastrointestinal side effects. The dose is then gradually increased every four weeks through 0.5 mg, 1 mg, and 1.7 mg until reaching the maintenance dose of 2.4 mg once weekly at week 17. Never skip the escalation schedule without guidance from your prescriber

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Thyroid hormone affects glucose homeostasis by ...