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Genetic predispositions in GLP-1 receptor variants and metabolic genessuch as GLP1R rs6923761 and FTO rs9939609may influence satiety response, weight loss trajectory, and side effect tolerance

Drug interactions remain minimal for both medications, though delayed gastric emptying may affect the absorption of oral medications

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Patients may require both medications simultaneously when managing multiple health conditionsfor example, someone with obesity and chronic neuropathic pain

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