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Cardiovasc Diabetol (2013) 12:117.10.1186/1475-2840-12-117 60 HattoriAKawamuraIYamadaYKanamoriHAoyamaTUshikoshiHet alElevated plasma GLP-1 levels and enhanced expression of cardiac GLP-1 receptors as markers of left ventricular systolic dysfunction: a cross-sectional study

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In addition, prolonged exposure to pharmacologic doses of long-acting GLP-1 RAs induces tachyphylaxis for the effects on gastric emptying, and that is why nausea vanishes quickly after the beginning of treatment in most patients [19]

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