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Protocol 1: semaglutide microdose for autoimmune inflammation Goal: Reduce systemic inflammation and autoimmune flare frequency Starting dose: 0.05 mg semaglutide subcutaneously, once weekly Week 1 to 4: Hold at 0.05 mg

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35 Under normal circumstances, islet beta-cell morphology is characterised by a large and stable number of intracellular mature insulin vesicles, which is sustained through the balance between biosynthesis, degradation and secretion

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The meta-regression shows that after 1 year of treatment withdrawal, participants regain 60% of the weight they lost during treatment