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GLP-1 RAs and naltrexone/bupropion have shown efficacy in attenuating hedonic drive through hypothalamic and mesolimbic modulation, offering therapeutic tools beyond caloric restriction [200]

Here are some simple strategies to boost GLP-1 activity naturally: 1

A sustained 14 mmHg reduction in systolic pressure translates to roughly a 40 to 50% reduction in stroke risk and a 20 to 30% reduction in coronary events over the long term

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