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The structure of exendin-4 in complex with the N-terminus domain of the human GLP-1R 17 (Protein Data Bank code 3C5T) was then used to rationally guide the location of the cysteines in the -helix of the peptide and in the linker or peptide C-terminus to minimize the impact on receptor binding and to favour disulphide bridge formation in order to reduce propensity to aggregate (Fig

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Novo Nordisks regulatory exclusivity for semaglutide ended on Jan

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