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Description
Fecal elimination represents approximately 13% of the dose

The activated Akt subsequently modulates many downstream effector proteins associated in cell survival, proliferation, metabolism, and glucose transport (Fletcher et al

These immunomodulatory effects complement their metabolic actions, contributing to improved liver outcomes and systemic benefits

Subsequently, the sequence of GLP-1 was identified following the cloning of the glucagon cDNAs and genes, soon followed by the demonstration that GLP-1 potentiated glucose-dependent insulin secretion in cells, animals, and humans (comprehensively reviewed in Drucker, et al

10.1016/j.phrs.2024.107401 22 FrasJ

This means insulin is released only when blood glucose levels are elevated, thereby reducing the risk of hypoglycaemia compared to some other diabetes medications
